Key result
Diabetes was associated with anatomic and histochemical lesions of the urinary bladder autonomic nerve fibers in 100% of patients, compared to 0% of nondiabetic controls.
Why the study?
Are there histological and histochemical alterations in the autonomic nerve fibers of the urinary bladder in diabetic patients compared to nondiabetic subjects?
Population
10 diabetic patients (5 examined by biopsy, 4 by autopsy, 1 with chemical diabetes) and 8 nondiabetic subjects
Comparison
Histological and histochemical analysis of… vs 8 nondiabetic subjects
Design
Case-control
Authors
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May link autonomic neuropathy to diabetic cystopathy; hypothesis-generating and should not yet change practice.
Observational (n=18)
Are there histological and histochemical alterations in the autonomic nerve fibers of the urinary bladder in diabetic patients compared to nondiabetic subjects?
Absolute Event Rate: 100% vs 0%
Diabetic neuropathy is associated with structural and histochemical damage to the autonomic nerve fibers of the urinary bladder, suggesting early biochemical injury to the myelin sheath.
Faerman et al. (1973) conducted an observational in Diabetes (n=18). Diabetes vs. Nondiabetic subjects was evaluated on Anatomic or histochemical lesions of the autonomic nerve fibers of the urinary bladder wall. Diabetes was associated with anatomic and histochemical lesions of the urinary bladder autonomic nerve fibers in 100% of patients, compared to 0% of nondiabetic controls.
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