Key result
Nitric oxide broadly regulates cellular signaling across vascular, immune, neural, and aging pathways.
Why the study?
Nitric oxide is recognized as a key signalling molecule in various physiological processes, but its regulatory roles across different cellular functions require comprehensive synthesis.
Nitric oxide is a key signaling molecule involved in vascular biology, immunity, inflammation, and other physiological processes.
Reaffirms nitric oxide's established role in vascular and immune function; leaves open targeted therapeutic translation in cardiovascular disease.
[First paragraph] Nitric oxide (NO) is a gaseous messenger molecule synthesized from L-arginine and molecular oxygen by three different NO synthases, that is, neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) form [1]. Since its discovery in the early 1980s by the three Nobel Laureates Furchgott, Ignarro & Murad [2], NO has been widely recognised as an important signalling molecule in many physiological processes. The initial identification of NO as an endothelium-derived relaxing factor (EDRF) [3] generated great interest in its function in vascular biology. Over the following years, however, the focus on NO research rapidly expanded from the vascular system to its role in immunity and inflammation, the nervous system, pregnancy, aging, and cell death.
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Sobrevía et al. (2015) reported a review. Nitric oxide was evaluated. Nitric oxide is a widely recognized signaling molecule that regulates cellular function in vascular biology, immunity, inflammation, the nervous system, pregnancy, aging, and cell death.
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