Key result
Music therapy added to antidepressants significantly improves nonlinear HRV parameters in major depressive disorder.
Why the study?
Non linear measures of heart rate variability are emerging methods to detect changes in cardiac autonomic nerve function in major depressive disorder, but the effect of music therapy on these measures was not established.
Does music therapy added to mirtazapine improve non linear measures of heart rate variability in newly diagnosed MDD patients?
Population
60 newly diagnosed MDD patients aged 20-40 years and matched healthy controls
Comparison
Music therapy with Raga kafi plus mirtazapine vs mirtazapine alone
Design
Prospective interventional study
Follow-up
3 months
Authors
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Music therapy adjunct may improve nonlinear HRV in MDD; hypothesis-generating and requires RCTs before any practice consideration.
Does music therapy added to mirtazapine improve non linear measures of heart rate variability in newly diagnosed MDD patients?
Music therapy added to antidepressant medication may improve cardiac autonomic nerve function by increasing parasympathetic and reducing sympathetic activity in patients with major depressive disorder.
Islam et al. (2019) studied Major depressive disorder (n=60). Music therapy with Raga kafi (Rabindrasangeet) plus Mirtazapine vs. Mirtazapine alone was evaluated on Non linear measures of heart rate variability (SD1, SD2, SD1/SD2). Music therapy combined with antidepressants for 3 months significantly increased non linear HRV parameters (SD1, SD2, SD1/SD2) in patients with major depressive disorder.
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