Key result
Chromosome 9p21 rs1333049 variant is linked to ~48% higher MI risk, but not post-MI outcomes.
Why the study?
The association of rs1333049 polymorphism on chromosome 9p21 with myocardial infarction and clinical outcomes in Han Chinese was unclear.
Is the rs1333049 polymorphism on chromosome 9p21 associated with myocardial infarction and post-MI clinical outcomes in Han Chinese?
Case-Control (n=1,080)
No
Is the rs1333049 polymorphism on chromosome 9p21 associated with myocardial infarction and post-MI clinical outcomes in Han Chinese?
Odds Ratio: 1.48 (95% CI 1.22–1.79)
Absolute Event Rate: 55.5% vs 46.2%
p-value: p=<0.01
The rs1333049 polymorphism on chromosome 9p21 increases susceptibility to a first acute myocardial infarction in Han Chinese but does not impact post-MI prognosis or angiographic severity.
Supports MI risk link for 9p21 variant in Han Chinese; leaves open effects on CAD severity or post-MI outcomes.
BACKGROUND: rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese. METHODS: rs1333049 polymorphism was genotyped in 520 patients with a first acute MI and in 560 controls. The number of angiographically documented diseased coronary arteries (luminal diameter stenosis > or = 50%), echocardiographic left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACE) during follow-up (mean, 29+/-15 months) were recorded. RESULTS: Patients with MI had higher frequencies of the CC genotype (30.0% vs. 20.7%) or C allele (55.5% vs. 46.2%) compared with controls (all p<0.01). rs1333049 polymorphism was strongly associated with MI [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.22-1.79] after adjusting for traditional risk factors. Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI. CONCLUSIONS: This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI, but not with post-MI prognosis in Han Chinese.
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Peng et al. (2009) conducted a case-control in Myocardial Infarction (n=1,080). rs1333049 polymorphism (C allele) on chromosome 9p21 vs. Non-carriers (GG/GC genotypes) / Controls was evaluated on Myocardial infarction susceptibility (OR 1.48, 95% CI 1.22-1.79, p=<0.01). The rs1333049 polymorphism on chromosome 9p21 was significantly associated with an increased risk of myocardial infarction (OR 1.48) in Han Chinese, but not with post-MI clinical outcomes.
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