Key result
A daily dose of 80 mg of aspirin resulted in 67% (95% CI 45-84%) of women with twin pregnancies being nonresponsive to the treatment, suggesting this dose is insufficient.
Why the study?
Does aspirin 80 mg daily improve birth weight and prevent preeclampsia in women with twin pregnancies?
RCT (n=50)
Double-blind
randomized
Does aspirin 80 mg daily improve birth weight and prevent preeclampsia in women with twin pregnancies?
p-value: p=0.49
A daily dose of 80 mg of aspirin is likely insufficient to achieve platelet inhibition and prevent placenta-mediated complications in twin pregnancies.
No takes yet. Share an insight, caveat, or question.
Pilot data leave 80 mg aspirin efficacy in twins unproven; larger RCTs needed before clinical adoption.
Carpentier et al. (2021) conducted an RCT in twin pregnancies (n=50). Aspirin vs. Placebo was evaluated on birth weight of live infants, preeclampsia, and aspirin responsiveness evaluated by a platelet aggregation test (platelet function assay [PFA]-100) (95% CI 45-84, p=0.49). A daily dose of 80 mg of aspirin resulted in 67% (95% CI 45-84%) of women with twin pregnancies being nonresponsive to the treatment, suggesting this dose is insufficient.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: