Key result
CAD is linked to higher plasma catecholamines, with postexercise SBP increases tracking higher norepinephrine.
Why the study?
The relationship between sympathetic activity and postexercise systolic blood pressure and exercise-induced ventricular arrhythmias in patients with coronary artery disease was not well understood.
How do plasma catecholamine responses to dynamic exercise relate to postexercise systolic blood pressure and exercise-induced ventricular arrhythmias in patients with coronary artery disease?
Population
38 patients with coronary artery disease and 9 normal subjects
Design
Observational study with treadmill testing
Follow-up
Immediately after exercise
Authors
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May differentiate norepinephrine- versus epinephrine-linked exercise responses in CAD; hypothesis-generating for targeted sympatholysis.
Observational (n=47)
How do plasma catecholamine responses to dynamic exercise relate to postexercise systolic blood pressure and exercise-induced ventricular arrhythmias in patients with coronary artery disease?
p-value: p=<0.05
In patients with CAD, postexercise systolic blood pressure increases are related to augmented sympathoneural activity (norepinephrine), whereas exercise-induced ventricular arrhythmias are related to augmented sympathoadrenal activity (epinephrine).
Miyakoda et al. (1992) conducted an observational in Coronary artery disease (n=47). Coronary artery disease vs. Normal subjects was evaluated on Plasma concentrations of norepinephrine and epinephrine at rest and immediately after exercise (p=<0.05). Patients with coronary artery disease had significantly higher plasma catecholamines than normal subjects, with postexercise systolic blood pressure increases linked to higher norepinephrine (p<0.05).
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