Key result
Sun's procedure carries ~27% operative mortality in Marfan patients with post-Bentall type A dissection.
Why the study?
Stanford type A aortic dissection involving the aortic arch after prior Bentall procedure in Marfan syndrome patients is uncommon and outcomes of total arch replacement with frozen elephant trunk in this group are not well defined.
What are the early and long-term outcomes of Sun's procedure (TAR + FET) for type A aortic dissection involving the aortic arch after a prior Bentall procedure in patients with Marfan syndrome?
Cohort (n=11)
What are the early and long-term outcomes of Sun's procedure (TAR + FET) for type A aortic dissection involving the aortic arch after a prior Bentall procedure in patients with Marfan syndrome?
Sun's procedure for type A aortic dissection involving the aortic arch after a previous Bentall procedure in Marfan patients is technically feasible with good long-term outcomes, though associated with high early mortality.
Objective Stanford type A aortic dissection(TAAD) involving aortic arch in following prior Bentall procedure in patients with Marfan syndrome(MFS) is uncommon. The purpose of the study was to assess the early and long-term outcomes of this kind of patients underwent total arch replacement and frozen elephant trunk(TAR + FET). Methods Between February 2009 and February 2016, 141 patients with Marfan syndrome(confirmed by revised Ghent Criteria) underwent TAR+ FET for TAAD, of those 11(7.8%) patients(8 acute) following a prior Bentall procedure and without dissection in distal aorta. Mean age at FET was(43.2±8.6) years and 10 were males. Hypertension was seen in 4(36.4%) and family history was seen in 7(63.6%). The interval from Bentall procedure to FET averaged(11.3±5.8) years. Two groups were segregated by the maximal diameter of descending aorta more than 40 mm or not. The early and long-term outcomes were analyzed and risk factors identified for late adverse events. Results Operative mortality was 27.3%(3/11). No spinal cord injury occurred. The cause of death was long time of surgery, multiorgan failure, stroke and cerebral hemorrhage and rupture of distal aorta. Follow-up was complete in 100%, averaging(5.3±2.0)years(range 2.1-8.1 years). Obliteration of the false lumen was seen in 100% across the proximal FET and 75.0% in the unstented descending aorta. Distal aortic dilation occurred in 3 patients which were waiting open thoracoabdominal aortic repair(TAAAR) but no reoperation yet. Of those 8 patients, 2 died of non-cardiac reason. The DMax of FET segment has significant grow in DA more than 40mm group than less than 40mm group(P= 0.01). Another segment of distal aorta has no significant different. Survival were 81.8%, 72.7% and 63.6% at 1month, 1 year and 6 years after surgery. Conclusion Using Sun’s procedure for Marfan patients for type A aortic dissection involving aortic arch following previous Bentall procedure was safe and technically feasible with good long-term outcomes, but higher early death. The DMax of descending aorta more than 40mm was at higher risk for early death, late distal aortic dilation, and reoperation.
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Chen et al. (2018) conducted a cohort in Type A aortic dissection involving aortic arch following prior Bentall procedure in Marfan syndrome (n=11). Total arch replacement and frozen elephant trunk (Sun's procedure) was evaluated on Operative mortality. Total arch replacement and frozen elephant trunk (Sun's procedure) in Marfan patients with type A aortic dissection after a Bentall procedure had 27.3% operative mortality and 63.6% 6-year survival.
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