December 10, 2014Current Vascular Pharmacology
Exploring In-hospital Death from Myocardial Infarction in Eastern Europe: From the International Registry of Acute Coronary Syndromes in Transitional Countries (ISACS-TC); on the Behalf of the Working Group on Coronary Pathophysiology & Microcirculation of the European Society of Cardiology
Key result
Lower primary PCI rates in Eastern Europe linked to ~2-fold higher in-hospital STEMI mortality.
- n=23,486
Why the study?
In-hospital STEMI case-fatality rates and outcomes of coronary reperfusion therapies in Eastern European countries with economies in transition were not well characterized compared to Western countries.
What are the outcomes of coronary reperfusion therapies and in-hospital mortality for STEMI patients in Eastern European countries compared to Western countries?
Population
23,486 consecutive STEMI patients admitted to hospitals in Eastern European transitional economies in 2009
Comparison
Coronary reperfusion therapies and STEMI outcomes in Eastern countries versus OECD Western countries
Design
Observational registry-based cohort study
Follow-up
In-hospital
Authors
Discussion
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Member takes
Implication
STEMI in-hospital mortality was higher in transitional Eastern countries versus OECD; associated with low reperfusion rates and leaves optimal strategies open for research.
Study Design
Type
Observational (n=23,486)
Multicenter
Yes
Structured PICO
What are the outcomes of coronary reperfusion therapies and in-hospital mortality for STEMI patients in Eastern European countries compared to Western countries?
P
Population
23,486 consecutive patients with STEMI admitted to hospitals in Eastern European countries during 2009, compared with registry data from OECD countries.
E
Exposure
Coronary reperfusion therapies (primary percutaneous coronary intervention)
C
Comparator
Registry data and statistics from Organization for Economic Cooperation and Development (OECD) countries (Western countries) for the same period (2009-2010)
O
Outcome
In-hospital mortalityhard clinical
In-hospital STEMI mortality varies widely in former Eastern Bloc countries and is often significantly higher than in Western countries, driven by lack of reperfusion therapy and longer delays to hospital presentation.
Cite This Study
Bugiardini et al. (2014) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=23,486). STEMI care in Eastern European countries vs. STEMI care in Western (OECD) countries was evaluated on In-hospital mortality. In-hospital STEMI mortality was higher in Eastern European countries like Serbia (10.8%) and Bosnia and Herzegovina (11.2%) compared to Western countries (4-5%), associated with low primary PCI rates.