Key result
Wirelessly powered leadless BiV pacing matches intrinsic QRS duration and stroke volume in preclinical testing.
Why the study?
About 30% of patients with impaired cardiac function have ventricular dyssynchrony and seek cardiac resynchronization therapy, motivating development of leadless BiV pacing.
Can miniaturized, wirelessly powered leadless pacemakers achieve synchronized biventricular pacing in a porcine model?
Population
Porcine model in open-chest and closed-chest settings
Comparison
Synchronized biventricular pacing using wirelessly powered leadless pacemakers
Design
Preclinical study with epicardial implantation of miniaturized pacemakers
Authors
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Wireless BiV pacing feasible preclinically; leaves open safety, efficacy, and translation to human CRT.
Can miniaturized, wirelessly powered leadless pacemakers achieve synchronized biventricular pacing in a porcine model?
Wirelessly powered leadless pacemakers can successfully achieve synchronized biventricular pacing in a closed-chest porcine model with low power requirements and safe specific absorption rates, offering a potential future approach for cardiac resynchronization therapy.
Lyu et al. (2020) studied Ventricular dyssynchrony (animal model) (n=1). Wirelessly powered leadless pacemakers for biventricular pacing vs. Right ventricular pacing and intrinsic rhythm was evaluated on QRS duration and velocity-time integral (VTI). Wirelessly powered leadless pacemakers successfully delivered synchronized biventricular pacing in a closed-chest porcine model, achieving QRS durations and stroke volumes comparable to intrinsic heartbeats.
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