Key result
Two sequential RV leadless pacemakers show no effect on cardiac function in swine.
Why the study?
Many patients may require at least two leadless pacemakers in their lifetime, but the effect of multiple devices in the right ventricle on cardiac function was unknown.
Does the implantation of multiple leadless pacemakers in the right ventricle impact cardiac function in a swine model?
Does the implantation of multiple leadless pacemakers in the right ventricle impact cardiac function in a swine model?
Implanting multiple leadless pacemakers in the right ventricle does not appear to negatively impact cardiac function or tricuspid valve integrity in a swine model.
No takes yet. Share an insight, caveat, or question.
Implanting two leadless pacemakers appears safe without cardiac impact in swine; leaves open translation to humans and long-term durability.
Chen et al. (2016) studied this question. Two sequential leadless pacemakers vs. Baseline was evaluated on Cardiac function (left ventricular ejection fraction, aortic time integral, cardiac output, and left ventricular size). Implantation of two sequential leadless pacemakers in the right ventricle of swine resulted in no significant changes in cardiac function, with mean fibrous tissue coverage of 14.3 mm.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: