Key result
Transaortic LV lead placement proves feasible in pigs without significant regurgitation or thromboembolism over six months.
Why the study?
Is direct transaortic placement of a left ventricular lead feasible and safe in a minipig model?
Is direct transaortic placement of a left ventricular lead feasible and safe in a minipig model?
Direct transaortic placement of a left ventricular lead is feasible in a porcine model, with acceptable lead function and no significant aortic regurgitation or thromboembolism at 6 months.
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May guide alternative CRT lead development; leaves open translation to human use.
Reinig et al. (2007) studied Left ventricular endocardial pacing (animal model) (n=10). Transaortic left ventricular lead placement vs. Polyurethane vs silicone lead was evaluated on Feasibility, aortic valve damage, systemic embolization, and pacing lead maturation and function. Direct transaortic placement of a left ventricular lead was feasible in a pig model, with no significant aortic regurgitation or thromboembolism after six months despite no anticoagulation.
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