EDITOR, - We wish to amplify the case reports of C A O' Callaghan and colleagues1 by reporting on a patient who developed acute renal failure twice: once after taking ibuprofen orally and once after topical administration of the drug. A 76 year old man was admitted with acute anuric renal failure five days after taking four tablets of ibuprofen for a muscle strain. In the 48 …
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Fernando et al. (1994) studied this question.
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