Key result
Genetically predicted serum uric acid shows no causal association with atrial fibrillation.
Why the study?
The causal effect of serum uric acid on the risk of atrial fibrillation remains unknown despite observational associations.
Does genetic predisposition to higher serum uric acid levels causally increase the risk of atrial fibrillation?
Observational (n=4,166)
Yes
Does genetic predisposition to higher serum uric acid levels causally increase the risk of atrial fibrillation?
Odds Ratio: 1.07 (95% CI 0.57–2.01)
p-value: p=.832
Although observational data links serum uric acid to atrial fibrillation, Mendelian randomization using a weighted genetic risk score did not support a causal relationship, despite one specific SNP showing an association.
Supports independent UA-AF link after adjustment; leaves open causality and whether urate lowering alters AF risk.
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Hong et al. (2020) conducted an observational in Atrial fibrillation (n=4,166). Serum uric acid was evaluated on Atrial fibrillation (OR 1.07, 95% CI 0.57-2.01, p=.832). Genetically predicted serum uric acid using a weighted genetic risk score was not causally associated with atrial fibrillation (OR 1.07; 95% CI 0.57-2.01; P=0.832).
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