Key result
Acute hypervolemia blunts early phase II Valsalva systolic pressure drops by ~23 mmHg vs hypovolemia.
Why the study?
The effects of changes in blood volume on arterial pressure patterns during the Valsalva maneuver are incompletely understood.
Does acute manipulation of plasma volume alter arterial pressure and heart rate responses during Valsalva maneuvers?
Population
Subjects undergoing supine Valsalva maneuvers
Comparison
Hypovolemia induced with intravenous furosemide vs hypervolemia induced with isotonic saline ingestion vs normovolemia
Design
Physiological study measuring beat-to-beat arterial pressure and heart rate responses
Authors
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Volume status alters Valsalva phase II pressure responses; supports accounting for volume in clinical autonomic testing and research.
Does acute manipulation of plasma volume alter arterial pressure and heart rate responses during Valsalva maneuvers?
Absolute Event Rate: -7.4% vs -30.7%
p-value: p=0.005
Acute changes in intravascular volume significantly alter arterial pressure and heart rate responses to the Valsalva maneuver, which should be accounted for in clinical and research applications.
Fritsch-Yelle et al. (1999) studied this question. Hypervolemia (ingestion of isotonic saline) vs. Hypovolemia (intravenous furosemide) was evaluated on Systolic pressure falls during early phase II of the Valsalva maneuver (p=0.005). Acute hypervolemia resulted in significantly smaller early phase II systolic arterial pressure falls during the Valsalva maneuver compared to hypovolemia (-7.4 vs -30.7 mmHg; P=0.005).
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