What does this research mean for the field?

Superoxide production by circulating mononuclear cells is significantly increased in diabetic patients with hypertriglyceridemia and correlates positively with plasma triglyceride levels. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1988Diabetes

Increased Superoxide Production by Mononuclear Cells of Patients With Hypertriglyceridemia and Diabetes

Q: What are the key findings of this study?

Superoxide production by mononuclear cells was significantly higher in diabetic hypertriglyceridemic patients than in normal, diabetic, or hypertriglyceridemic groups, correlating with plasma triglycerides (P<0.01).

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Diabetes mellitus and hypertriglyceridemia. Intervention: Diabetic hypertriglyceridemia vs. Normal, solely diabetic, and solely hypertriglyceridemic groups. Primary outcome: Rate of production of superoxide dismutase-inhibitable O2- by mononuclear cells (r = 0.73 (PMA) and r = 0.79 (OZ), p=<0.01).

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Key result

Diabetic hypertriglyceridemia is linked to increased mononuclear cell superoxide production correlating with triglyceride levels.

r = 0.73 (PMA) and r = 0.79 (OZ)
P<0.01

Why the study?

Diabetic patients with hypertriglyceridemia frequently develop atherosclerosis, and the role of superoxide production by mononuclear cells in this process was investigated.

Does the combination of diabetes and hypertriglyceridemia increase superoxide production by mononuclear cells compared to either condition alone or normal controls?

Population

Patients divided into normal, solely diabetic, solely hypertriglyceridemic, and diabetic hypertriglyceridemic groups

Comparison

Mononuclear cell superoxide production in diabetic hypertriglyceridemic vs normal, diabetic, and hypertriglyceridemic groups

Design

Observational cross-sectional study measuring superoxide production ex vivo

Authors

KHKazuko HiramatsuUniversity of Wyoming SAS ArimoriKeiai University

Discussion

Member takes

Implication

May implicate oxidative stress in atherosclerosis risk for diabetic hypertriglyceridemia; leaves open whether superoxide-targeted interventions alter outcomes.

Study Design

Type

Observational

Structured PICO

Does the combination of diabetes and hypertriglyceridemia increase superoxide production by mononuclear cells compared to either condition alone or normal controls?

Population

Patients divided into four groups: normal, solely diabetic, solely hypertriglyceridemic, and diabetic hypertriglyceridemic.

Exposure

Ex vivo stimulation of circulating mononuclear cells by 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA) or opsonized zymosan (OZ)

Comparator

Normal, solely diabetic, and solely hypertriglyceridemic groups

Outcome

Rate of production of superoxide dismutase-inhibitable O2-surrogate

Main Result

Effect estimate: r = 0.73 (PMA) and r = 0.79 (OZ)

p-value: p=<0.01

Elevated superoxide production in mononuclear cells of diabetic hypertriglyceridemic patients is driven by hypertriglyceridemia and may contribute to atherosclerosis pathogenesis.

Cite This Study

Hiramatsu et al. (1988) conducted an observational in Diabetes mellitus and hypertriglyceridemia. Diabetic hypertriglyceridemia vs. Normal, solely diabetic, and solely hypertriglyceridemic groups was evaluated on Rate of production of superoxide dismutase-inhibitable O2- by mononuclear cells (r = 0.73 (PMA) and r = 0.79 (OZ), p=<0.01). Superoxide production by mononuclear cells was significantly higher in diabetic hypertriglyceridemic patients than in normal, diabetic, or hypertriglyceridemic groups, correlating with plasma triglycerides (P<0.01).

synapsesocial.com/papers/6ab7856d3a343901de976e2a https://doi.org/10.2337/diab.37.6.832

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Implication

May implicate oxidative stress in atherosclerosis risk for diabetic hypertriglyceridemia; leaves open whether superoxide-targeted interventions alter outcomes.

Increased Superoxide Production by Mononuclear Cells of Patients With Hypertriglyceridemia and Diabetes

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Increased Superoxide Production by Mononuclear Cells of Patients With Hypertriglyceridemia and Diabetes

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider