Why the study?
Does NOS III uncoupling contribute to increased platelet superoxide production in patients with hypertension and coexistent diabetes mellitus?
Population
Patients with hypertension alone and patients with coexistent diabetes mellitus and hypertension
Comparison
Ex vivo stimulation of gel-filtered platelets… vs Patients with hypertension alone
Design
Cross-sectional
Authors
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Supports greater platelet oxidative stress with comorbid diabetes; hypothesis-generating for NOS III uncoupling in hypertension.
Does NOS III uncoupling contribute to increased platelet superoxide production in patients with hypertension and coexistent diabetes mellitus?
NOS III uncoupling contributes significantly to increased superoxide production in patients with hypertension and diabetes, providing a mechanistic link to increased oxidative stress and cardiovascular risk.
Dixon et al. (2005) studied this question.
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