Transaminase and Creatinine Predict Diastolic and Systolic Dysfunction in Patients with Myocardial Infarction

Background: Acute myocardial infarction occurs due to coronary artery blockage usually caused by atherosclerotic clot or spasm of the arteries. Aspartate transaminase (AST or GOT) is found in the liver, heart (cardiac muscle), skeletal muscle, kidneys, brain, and red blood. Alanine aminotransferase cells (ALT or GPT) is mainly distributed in the liver, and increased serum ALT is a marker of liver injury. Creatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). Objectives: This study aimed to explore the level and relationship of serum alanine aminotransferase [ALT], aspartate aminotransferase [AST] and creatinine with different risk factors, systolic dysfunction, Diastolic dysfunction and Mitral Regurgitation in myocardial infarction. Patients and methods: A total of 90 patients were recruited and 20 healthy person as controls group. Initial coronary echocardiography was performed to evaluate the severity of coronary lesions, Serum GOT,GPT,Creatinine, glucose, lipid profile was done (within 24 h from admition) by colorimetric method in all patients group and control group. Estimation of Logistic regression analysis was employed for the evaluation of clinical characteristics and biochemical parameters, aiming to explore the relationship between biochemicals and CHD. Results: This study included 90 patients with mean±SD of age was (66.88±13.55) years, and (44.33±9.79) years for healthy control group, The patients with AMI were found to have significantly higher mean (± SD) value of serum GOT, GPT, and creatinine concentrations as compared with control group. The mean( SD) of serum GOT concentrations was found significantly higher in the Stage 1 than Stage 2 of Diastolic dysfunction (P-value≤ 0.05 ),while serum GPT concentrations was found non significantly higher in the Stage 2 than Stage1 of Diastolic dysfunction (P-value > 0.05 ). The serum creatinine concentrations was found significantly higher in the Stage 2 than Stage1 of Diastolic dysfunction (P-value≤ 0.001). The mean( SD) of serum GOT concentrations was found significantly higher in the absence of mitral regurgitation (MR) (P-value≤ 0.05 ),while serum GPT concentrations was found non significantly higher in the presence of MR (P-value> 0.05).There was highly significant difference in mean( SD) of serum creatinine concentrations in the presence of MR (P-value ≤ 0.001). Conclusions: Serum GPT, GOT, creatinine concentrations Predict early left ventricular ejection dysfunction. The serum creatinine concentrations and serum GPT concentrations was Predict early Diastolic dysfunction and Mitral Regurgitation in patients with myocardial infarction, there was non-significant changes in the serum concentrations of GOT, GPT and creatinine concentrations in the presence or absence of risk factor (Diabetes mellitus, Dyslipidemia, Hypertension, , Obesity, Smoking ), fibrinolysis treatment (Actilyse) and types of MI.