Key result
Serum arginase levels were significantly elevated in patients with unstable angina and myocardial infarction compared to controls (P<0.001).
Why the study?
Is serum arginase activity a useful cardiac marker for the differential diagnosis of unstable angina and myocardial infarction compared to healthy controls?
Case-Control (n=90)
No
Is serum arginase activity a useful cardiac marker for the differential diagnosis of unstable angina and myocardial infarction compared to healthy controls?
p-value: p=<0.001
Serum arginase activity is significantly elevated in acute coronary syndromes and may serve as a useful biomarker alongside traditional markers like AST and CK-MB.
Elevated arginase in ACS should not yet change practice; leaves open its diagnostic utility versus established markers.
The present study was undertaken to find the levels of aspartate transaminases (AST), creatine kinase (CK-MB) and arginase in serum sample of patients under study and check effectiveness of arginase as a marker in acute coronary syndrome (ACS), and to find the correlation between AST and CK-MB with arginase in unstable angina (UA) and myocardial infarction (MI). Study Design: Case control study carried out at department of Biochemistry, B. J. Medical College Pune, Maharashtra, India, between Sept 2011-Dec 2013. Methodology: The study comprised of clinically diagnosed 60 patients: 30 of UA and 30 of MI. Age and sex matched 30 patients were studied as controls. Blood sample were collected from individual under study, serum was separated and used to estimate levels of CK-MB, AST and arginase. Results: The levels of AST, CK-MB and arginase were estimated and the results were compared with that of control. The levels of arginase were elevated significantly (P<0.001) like AST and CK-
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Yerawar et al. (2014) conducted a case-control in Acute coronary syndrome (unstable angina and myocardial infarction) (n=90). Serum arginase levels vs. Age and sex matched controls was evaluated on Serum arginase levels (p=<0.001). Serum arginase levels were significantly elevated in patients with unstable angina and myocardial infarction compared to controls (P<0.001).
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