Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 19, 2026Romanian Journal of CardiologyOpen Access

Predictors of no-reflow phenomenon in patients with type 2 diabetes mellitus undergoing elective percutaneous coronary intervention: the emerging role of the triglyceride–glucose index

View Full Paper
Ask AI
Bookmark
Share

Key result

Higher TyG index predicts ~105% greater no-reflow risk per 0.1-unit increase during elective PCI in T2D.

  • OR 2.05
  • 95% CI 1.26-3.32
  • P=0.004
  • n=137

Why the study?

The prevalence and predictors of the no-reflow phenomenon in patients with type 2 diabetes mellitus undergoing elective PCI and the predictive value of the triglyceride–glucose index were not well established.

Does the triglyceride-glucose (TyG) index predict the no-reflow phenomenon in patients with type 2 diabetes mellitus undergoing elective percutaneous coronary intervention?

Population

137 patients with type 2 diabetes mellitus undergoing elective PCI at two tertiary centres

Comparison

No-reflow group vs normal reflow group based on postprocedural TIMI flow grade

Design

Prospective observational cohort study

Follow-up

Postprocedural

Authors

HBHala Mahfouz BadranCardiac ImagingMMMohamed Kadry Ghazy MohamedMenoufia UniversityGSGhada Mahmoud SoltanMenoufia University

Discussion

Loading...

Member takes

Implication

May inform preprocedural no-reflow risk stratification in diabetic elective PCI; extends observational data but leaves open prospective validation.

Study Design

Type

Cohort (n=137)

Multicenter

Yes

Structured PICO

Does the triglyceride-glucose (TyG) index predict the no-reflow phenomenon in patients with type 2 diabetes mellitus undergoing elective percutaneous coronary intervention?

P
Population
137 adults with type 2 diabetes mellitus undergoing elective percutaneous coronary intervention for stable coronary artery disease.
E
Exposure
Triglyceride-glucose (TyG) index as a preprocedural risk stratification marker
O
Outcome
No-reflow phenomenon, defined as postprocedural Thrombolysis in Myocardial Infarction (TIMI) flow grade ≤2 in the absence of angiographically evident mechanical obstruction, dissection or thrombussurrogate

Main Result

Odds Ratio: 2.05 (95% CI 1.26–3.32)

p-value: p=0.004

The triglyceride-glucose index is a strong, independent predictor of the no-reflow phenomenon in patients with type 2 diabetes undergoing elective PCI, offering a simple tool for preprocedural risk stratification.

Limitations

  • Single-centre observational study with a modest sample size
  • Only 13 no-reflow events occurred, yielding a low events-per-variable ratio
  • Optimal TyG cutoff was derived and evaluated within the same cohort
  • No-reflow was defined using angiographic TIMI flow grade alone without more sensitive indices of microvascular perfusion
  • Only intracoronary nitroglycerine was administered when impaired flow was encountered
  • Stenosis severity and TIMI flow were assessed by visual estimation rather than quantitative coronary angiography
  • Direct measures of insulin resistance were not collected
  • Long-term clinical outcomes were not evaluated
  • Optimal TyG cutoff was both derived and evaluated within the same cohort

Cite This Study

Badran et al. (2026) conducted a cohort in Type 2 diabetes mellitus undergoing elective percutaneous coronary intervention (n=137). Triglyceride-glucose (TyG) index vs. Lower TyG index was evaluated on No-reflow phenomenon (TIMI flow grade ≤2) (OR 2.05, 95% CI 1.26-3.32, p=0.004). The triglyceride-glucose index was an independent predictor of the no-reflow phenomenon in patients with type 2 diabetes undergoing elective percutaneous coronary intervention (OR 2.05 per 0.1-unit increase).

synapsesocial.com/papers/6ab78a8594d2a76640d586dfhttps://doi.org/10.2478/rjc-2026-0024

Topics

Percutaneous coronary intervention
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictors of No-Reflow Phenomenon: Diabetes Mellitus type II and Obesity and their Associated Mortality in Stemi Patients after Primary PCI2019 · 2 citations
  2. 2The Use of Thrombectomy during Primary Percutaneous Coronary Intervention: Resurrecting an Old Concept in Contemporary Practice2024 · 9 citations
  3. 3The triglyceride-glucose index and neutrophil-to-lymphocyte ratio jointly predict the no-reflow phenomenon in T2DM patients with STEMI after primary PCI2026 · 2 citations
  4. 4A Novel Marker Triglyceride Glucose Index in Predicting the Development of No-reflow in Acute Coronary Syndrome without ST-segment Elevation2024 · 1 citations
  5. 5Prediction of no-reflow phenomenon in elective percutaneous coronary intervention for non-acute myocardial infarction2026 · 2 citations