Key result
RemoveLL filter device significantly reduces end-bypass leukocyte counts during CPB without compromising platelets or hematocrit.
Why the study?
The effectiveness of a new oxygenator-integrated device for removing lipid particles and leukocytes from shed mediastinal blood during cardiopulmonary bypass was evaluated.
Does an oxygenator-integrated fat and leukocyte removal device reduce lipid particles and leukocytes in patients undergoing elective cardiac surgery under cardiopulmonary bypass?
Does an oxygenator-integrated fat and leukocyte removal device reduce lipid particles and leukocytes in patients undergoing elective cardiac surgery under cardiopulmonary bypass?
The use of an oxygenator-integrated fat and leukocyte removal device during cardiopulmonary bypass effectively reduces lipid particles and leukocytes without adversely affecting platelets or hematocrit.
Supports further evaluation of integrated leukocyte removal devices in CPB; leaves open effects on clinical outcomes.
We evaluated the effectiveness of a new oxygenator-integrated device for removing lipid particles and leukocytes from shed mediastinal blood in 20 patients undergoing elective cardiac surgery under cardiopulmonary bypass. Another 20 patients undergoing cardiac surgery without the device served as controls. After filtration with the RemoveLL device, lipid particles, leukocytes, and fats were significantly reduced compared to preoperative levels. In the control group, blood fats and lipid particles at the end of cardiopulmonary bypass were significantly increased compared to preoperative levels. Leukocyte counts at the end of bypass were significantly lower in patients who had the filtration device compared to the control group. Platelets counts and hematocrit changes were not significantly different between the 2 groups.
No takes yet. Share an insight, caveat, or question.
Dell’Amore et al. (2010) studied Elective cardiac surgery under cardiopulmonary bypass (n=40). RemoveLL oxygenator-integrated filtration device vs. Cardiac surgery without the device was evaluated on Lipid particles, leukocytes, and fats levels. The RemoveLL oxygenator-integrated device significantly reduced leukocyte counts at the end of bypass compared to controls, with no significant differences in platelet counts or hematocrit.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: