Case report demonstrates complete ulcer closure following topical ON101 application in a diabetic foot ulcer patient with exposed tendon, suggesting macrophage modulation rescues difficult wounds.
A 53-year-old woman with type 2 diabetes mellitus (DM), peripheral arterial disease (PAD), hypertension, and hyperlipidemia was sent to the emergency department with exposed tendon and soft tissue necrosis from a diabetic foot ulcer (DFU).After 10 days of treatment with broad-spectrum antibiotics and angioplasty, tissue proliferation was still halted by persistent inflammation.Despite multiple interventions, the wound did not heal.Therefore, the topical macrophage-modulating drug, ON101, was used twice daily.The ulcer area then completely closed after 16 weeks.In our study, macrophage modulation can be a new approach to promote tissue repair and rescue difficult wounds.
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Lin et al. (2022) studied this question.
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