What question did this study set out to answer?

To investigate the expression, biological functions, and molecular mechanisms of the long noncoding RNA LINC01132 in epithelial ovarian cancer progression.

February 23, 2021Open Access

Silencing of Long Noncoding RNA LINC01132 Alleviates the Oncogenicity of Epithelial Ovarian Cancer by Regulating the microRNA-431-5p/SOX9 Axis

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To investigate the expression, biological functions, and molecular mechanisms of the long noncoding RNA LINC01132 in epithelial ovarian cancer progression.
Quantified LINC01132 expression in epithelial ovarian cancer samples using RT-qPCR.
Assessed malignant phenotypes through Cell Counting Kit-8, flow cytometry apoptosis assays, transwell migration/invasion assays, and mouse tumor xenograft models.
Evaluated the molecular interactions between LINC01132, miR-431-5p, and SOX9 using RNA immunoprecipitation and luciferase reporter assays.
LINC01132 was significantly upregulated in epithelial ovarian cancer and associated with poor patient prognosis.
LINC01132 knockdown suppressed cancer cell proliferation, migration, invasion, and in vivo tumor growth while inducing apoptosis.
LINC01132 functioned as a competitive endogenous RNA to sponge miR-431-5p, thereby upregulating SOX9 expression to drive oncogenic behaviors.

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Implication

In vitro and in vivo study demonstrates that LINC01132 knockdown suppresses epithelial ovarian cancer progression via miR-431-5p and SOX9, suggesting a novel therapeutic target.

Cite This Study

Zhu et al. (2021) studied this question.

synapsesocial.com/papers/6ab86827e2aab15d116d1ce8 https://doi.org/10.21203/rs.3.rs-219226/v1

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Implication

In vitro and in vivo study demonstrates that LINC01132 knockdown suppresses epithelial ovarian cancer progression via miR-431-5p and SOX9, suggesting a novel therapeutic target.

Silencing of Long Noncoding RNA LINC01132 Alleviates the Oncogenicity of Epithelial Ovarian Cancer by Regulating the microRNA-431-5p/SOX9 Axis

Key Points

Discussion

Implication

Cite This Study

Silencing of Long Noncoding RNA LINC01132 Alleviates the Oncogenicity of Epithelial Ovarian Cancer by Regulating the microRNA-431-5p/SOX9 Axis

Key Points

Discussion

Implication

Cite This Study

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