Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 10, 2022Open Access

In patients with nonvalvular atrial fibrillation undergoing left atrial appendage closure, prior percutaneous coronary intervention did not significantly alter the risk of stroke or transient ischemic attack (2.8% vs 5.5%, p=1.000) compared to those without prior intervention.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does left atrial appendage closure (LAAC) safely and effectively prevent thromboembolic and bleeding events in NVAF patients with a history of PCI compared to those without PCI?

Population

109 consecutive patients with nonvalvular atrial fibrillation undergoing successful left atrial appendage…

Comparison

Left atrial appendage closure in NVAF patients… vs Left atrial appendage closure in NVAF patients…

Design

Cohort

Follow-up

median 20 months

Key result

In patients with nonvalvular atrial fibrillation undergoing left atrial appendage closure, prior percutaneous coronary intervention did not significantly alter the risk of stroke or transient ischemic attack (2.8% vs 5.5%, p=1.000) compared to those without prior intervention.

Authors

YYYunan YuJXJing XuLWLiang Wang

Discussion

Loading...

Member takes

Overview

LAAC may be feasible in NVAF patients post-PCI; hypothesis-generating and requires randomized trials before practice change.

Study Design

Type

Cohort (n=109)

Multicenter

Yes

Structured PICO

Does left atrial appendage closure (LAAC) safely and effectively prevent thromboembolic and bleeding events in NVAF patients with a history of PCI compared to those without PCI?

P
Population
109 patients with nonvalvular atrial fibrillation undergoing left atrial appendage closure, including 36 with prior percutaneous coronary intervention, followed for a median of 20 months.
E
Exposure
Left atrial appendage closure (LAAC) in NVAF patients with a history of percutaneous coronary intervention (PCI).
C
Comparator
Left atrial appendage closure (LAAC) in NVAF patients without a history of percutaneous coronary intervention (PCI).
O
Outcome
Peri-procedural and long-term complications, as well as ischemia and bleeding events (cardiovascular death, stroke/TIA, major bleeding, device-related thrombus) over a median 20-month follow-up.hard clinical

Main Result

Absolute Event Rate: 2.8% vs 5.5%

p-value: p=1.000

LAAC is a safe and effective option for stroke prevention in NVAF patients with a history of PCI, showing comparable long-term outcomes to those without PCI and reducing expected thromboembolic and bleeding events.

Limitations

  • Small sample size
  • Non-randomized observational design
  • Relatively short follow-up period of nearly 2 years
  • Potential subjective bias from phone-contact follow-up
  • Not a randomized trial
  • Nearly 2-year follow-up period might inadequately interpret the differences on clinical events between the two subgroups
  • Last follow-up using phone-contact is prone to subjective bias

Cite This Study

Yu et al. (2022) conducted a cohort in Nonvalvular atrial fibrillation (n=109). Percutaneous coronary intervention vs. No percutaneous coronary intervention was evaluated on Stroke or transient ischemic attack (p=1.000). In patients with nonvalvular atrial fibrillation undergoing left atrial appendage closure, prior percutaneous coronary intervention did not significantly alter the risk of stroke or transient ischemic attack (2.8% vs 5.5%, p=1.000) compared to those without prior intervention.

synapsesocial.com/papers/6ab86b9da31e7bb78447eaabhttps://doi.org/10.21203/rs.3.rs-1393057/v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left atrial appendage closure in nonvalvular atrial fibrillation patients with percutaneous coronary intervention2022 · 2 citations
  2. 2Left Atrial Appendage Closure in Patients with Atrial Fibrillation and Intermediate-to-Borderline High Cardiovascular Risk: A Retrospective Propensity Match Cohort Study2026
  3. 3Left Atrial Appendage Closure Yields Favorable Cardio- and Cerebrovascular Outcomes in Patients With Non-valvular Atrial Fibrillation and Prior Stroke2022 · 1 citations
  4. 4Percutaneous left atrial appendage closure in non-valvular atrial fibrillation with concomitant heart failure: a systematic review and meta-analysis of periprocedural and long-term outcomes2026
  5. 5Left atrial appendage closure: a new strategy for cardioembolic events despite oral anticoagulation2021 · 16 citations