Key result
The near-atomic cryo-EM structure of lizard atadenovirus LAdV-2 reveals a conserved capsid-binding motif and intergenera variations in cementing proteins, suggesting mastadenovirus E1B-55 K evolved from an LH3-like protein.
Population
Lizard atadenovirus LAdV-2
Comparison
High-resolution structural determination vs Mammalian-infecting mastadenoviruses
Design
Preclinical
Authors
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First nonmammalian adenovirus structure; extends capsid evolution models but leaves functional and translational implications open.
Provides the first high-resolution structure of a nonmammalian adenovirus, revealing evolutionary conservation and divergence in capsid proteins.
Marabini et al. (2021) studied Atadenovirus (LAdV-2) structure. Cryo-electron microscopy was evaluated on Near-atomic structure of LAdV-2. The near-atomic cryo-EM structure of lizard atadenovirus LAdV-2 reveals a conserved capsid-binding motif and intergenera variations in cementing proteins, suggesting mastadenovirus E1B-55 K evolved from an LH3-like protein.
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