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September 24, 2025Open Access

The structure of the Human Adenovirus 7 virus-like particles reveals that pentons and core-genome promote hexon-pIIIa interactions during capsid maturation

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Authors

KMKiyano MadooCity College of New YorkRMRyan MazboudiBoehringer Ingelheim (United Kingdom)RKRobert A. KuschnerCapiz State University

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Overview

Analysis reveals hexon-pIIIa interactions during capsid maturation in adenovirus-like structures, indicating potential for VLP vaccines.

Key Points

  • The cryo-EM structure confirms proper display of key epitopes, crucial for eliciting neutralizing antibodies against adenovirus infections.
  • Penton interactions with hexons and pIIIa are essential for the stabilization of the capsid, promoting effective immune responses.
  • Virus-like particles were found to promote a potent humoral immune response in mice, demonstrating potential for being a safer vaccine alternative.
  • Insights from the VLP structure guide the engineering of particles aimed at targeting various adenovirus types, improving vaccine efficacy.

Cite This Study

Madoo et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8ba8b2b6861e4c3ef4chttps://doi.org/10.1101/2025.09.22.677823
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