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January 1, 1994Journal of General Virology

Expression of a foreign epitope on the surface of the adenovirus hexon

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Population

Adenovirus type 2 hexon engineered with an eight amino acid sequence from the major antigenic site in the…

Comparison

Engineering the foreign sequence into two loop… vs Wild-type adenovirus

Design

Preclinical

Authors

JCJohn L. CromptonTexas CollegeCTC. I. A. ToogoodNational Institute for Medical ResearchNWN. WallisHebrew University of Jerusalem

Discussion

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Implication

Loop I substitutions enable epitope display on adenovirus hexon without impairing growth; hypothesis-generating for vector vaccines pending human data.

Structured PICO

P
Population
Adenovirus type 2 hexon engineered with an eight amino acid sequence from the major antigenic site in the VP1 capsid protein of poliovirus type 3
I
Intervention
Engineering the foreign sequence into two loop regions (loop I and loop II) of the adenovirus hexon
C
Comparator
Wild-type adenovirus
O
Outcome
Viral growth characteristics and recognition/neutralization by antiserasurrogate

It is feasible to alter the surface properties of the adenovirus virion by expressing a foreign epitope on the hexon, allowing manipulation of the immune response.

Cite This Study

Crompton et al. (1994) studied this question.

synapsesocial.com/papers/6a8013fc9b5ec1a88046fbc8https://doi.org/10.1099/0022-1317-75-1-133
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  2. 2A Cassette Vector for the Construction of Antigen Chimaeras of Poliovirus1989 · 24 citations
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  5. 5Mapping of a neutralizing antigenic site of Coxsackievirus B4 by construction of an antigen chimera1991 · 64 citations