Periodontal and Dental Outcomes of Regenerative Techniques Used in Intentional Replantation

Introduction: This review aimed to assess the effectiveness of different regenerative techniques in intentional replantation (IR), focusing on periodontal ligament (PDL) healing, pulp vitality, tooth survival rates, and the prevention of ankylosis.Methods: A thorough search was undertaken across numerous databases (Web of Science [345 articles], PubMed [452 articles], Scopus [398 articles], Embase [304 articles], Cochrane Library [249 articles], and manually [422 articles]) for studies utilizing regenerative materials in IR. A total of eight studies were combined to meet the inclusion criteria, comprising six non-randomized human clinical studies, one randomized controlled trial (RCT), and one animal study. Essential data regarding study design, sample size, regenerative materials, and clinical outcomes were extracted and analyzed.Results: The periodontal and pulp healing were enhanced by a variety of regenerative materials, including Bio-Oss, demineralized freeze-dried bone (DFDBA), concentrated growth factor (CGF), vascular endothelial growth factor (VEGF), enamel matrix derivative (EMD), and thymosin alpha 1 (Talpha1). Most studies discovered that changes in bone regeneration, tooth mobility, and PDL healing resulted in favorable outcomes. However, there was a discrepancy in the success rate of long-term tooth retention and ankylosis prevention. These regions underscore the necessity for additional high-quality research, as they particularly lack studies that utilize stem cell-based regenerative technologies and have only one pilot RCT available.Conclusion: Regenerative materials appear to enhance clinical outcomes in IR. The absence of standardized protocols, long-term data, and RCT underscores the necessity for further research to delineate optimal regenerative strategies and enhance long-term success rates.