Key result
Hypoxia in 25 mM glucose preferentially induced electrophysiological damage in isolated rat dorsal roots compared to 2.5 mM glucose, indicated by a lack of posthypoxic recovery.
Population
Isolated ventral and dorsal rat spinal roots
Comparison
Transient exposure to hypoxia in a solution of… vs Hypoxia in 2.5 mM extracellular glucose, or…
Design
Preclinical
Authors
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Sensory fibers show greater vulnerability to hyperglycemic hypoxia than motor fibers; hypothesis-generating for endoneurial hypoxia in diabetic neuropathy pathogenesis.
Sensory nerve fibers show greater sensitivity to hyperglycemic hypoxia than motor fibers, supporting the role of hypoxia and nerve acidosis in diabetic neuropathy.
Schneider et al. (1992) studied Diabetic neuropathy. Hypoxia in 25 mM extracellular glucose vs. Hypoxia in 2.5 mM glucose was evaluated on Electrophysiological damage (lack of posthypoxic recovery). Hypoxia in 25 mM glucose preferentially induced electrophysiological damage in isolated rat dorsal roots compared to 2.5 mM glucose, indicated by a lack of posthypoxic recovery.
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