Key result
L-NAME pretreatment significantly enhanced antigen-induced renal vasoconstriction and renal dysfunction in rats, where baseline anaphylaxis decreased creatinine clearance to 53%.
Why the study?
Does nitric oxide synthesis inhibition with L-NAME exacerbate renal vasoconstriction and dysfunction during anaphylaxis in rats?
Does nitric oxide synthesis inhibition with L-NAME exacerbate renal vasoconstriction and dysfunction during anaphylaxis in rats?
Nitric oxide appears to play a protective role against renal vasoconstriction and dysfunction during anaphylaxis in a rat model.
Anaphylaxis-related renal impairment may require monitoring in critical care; leaves open nitric oxide modulation as a therapeutic target pending human data.
We determined the renal responses to anaphylaxis and the effects of a nitric oxide synthesis inhibitor, L-NAME, in anesthetized rats and isolated perfused rat kidneys. After the ovalbumin antigen injection, the sensitized rats showed transient and substantial decreases in mean blood pressure and renal blood flow and an increase in renal vascular resistance. Creatinine clearance, a measure of renal function, decreased to 53% baseline at 2 h after antigen. L-NAME pretreatment significantly enhanced the antigen-induced renal vasoconstriction and renal dysfunction. Moreover, plasma creatinine levels significantly increased only in the L-NAME pretreated rats. Separately, in isolated perfused kidneys, we observed the antigen-induced renal vasoconstriction and its augmentation by L-NAME. In conclusion, the renal vascular response to the antigen is vasoconstriction, which is enhanced by L-NAME in both isolated perfused rat kidneys and anesthetized rats; it is accompanied by renal dysfunction, which is also augmented by L-NAME.
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Mukai et al. (2017) studied Anaphylaxis. L-NAME (nitric oxide synthesis inhibitor) vs. No L-NAME pretreatment was evaluated on Renal vasoconstriction and renal dysfunction. L-NAME pretreatment significantly enhanced antigen-induced renal vasoconstriction and renal dysfunction in rats, where baseline anaphylaxis decreased creatinine clearance to 53%.
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