Key result
Zero-contrast TAVR fails to reduce acute kidney injury over standard TAVR in advanced CKD.
Why the study?
The clinical utility of transcatheter aortic valve replacement without contrast medium in patients with advanced-stage chronic kidney disease remains unexplored.
Does zero-contrast imaging guided TAVR demonstrate feasibility and clinical utility in patients with severe chronic kidney disease?
Cohort (n=555)
No
Does zero-contrast imaging guided TAVR demonstrate feasibility and clinical utility in patients with severe chronic kidney disease?
This study explores the feasibility and clinical utility of performing TAVR without contrast medium in patients with advanced-stage chronic kidney disease.
Supports feasibility of zero-contrast TAVR without excess AKI in advanced CKD; hypothesis-generating and requires randomized confirmation.
Objective: The clinical utility of transcatheter aortic valve replacement (TAVR) without contrast medium in patients with advanced-stage chronic kidney disease (CKD) remains unexplored. We evaluated the feasibility and clinical utility of zero-contrast TAVR in patients with CKD.
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Yukimitsu et al. (2023) conducted a cohort in Symptomatic severe aortic stenosis and chronic kidney disease (n=555). Zero-contrast TAVR vs. TAVR with contrast was evaluated on Incidence of acute kidney injury (AKI) (p=0.06). Zero-contrast TAVR in patients with advanced chronic kidney disease resulted in no significant difference in acute kidney injury compared to contrast TAVR (11% vs. 4%, P=0.06), with no cases of stage 2-4 AKI.
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