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November 12, 2020Catheterization and Cardiovascular Interventions

Long‐term outcomes after transcatheter aortic valve replacement with minimal contrast in chronic kidney disease

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Why the study?

Patients with renal insufficiency have poor short-term outcomes after TAVR, prompting evaluation of long-term outcomes with minimal contrast.

Does baseline renal insufficiency affect long-term outcomes in patients undergoing TAVR with a minimal contrast approach?

Population

575 consecutive patients not on hemodialysis who underwent TAVR

Comparison

Preprocedural GFR ≥60 vs 30-60 vs <30 ml/min

Design

Retrospective chart review

Follow-up

Median 811 days

Authors

JRJustyna RzucidloVJVita JaspanDPDarien Paone

Discussion

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Member takes

Overview

Lower pre-TAVR GFR signals higher unadjusted long-term mortality; leaves open independent prognostic value after multivariable adjustment.

Structured PICO

Does baseline renal insufficiency affect long-term outcomes in patients undergoing TAVR with a minimal contrast approach?

P
Population
575 consecutive patients not on hemodialysis who underwent transcatheter aortic valve replacement (TAVR)
I
Intervention
Transcatheter aortic valve replacement (TAVR) with minimal contrast approach
C
Comparator
Comparison across different preprocedural glomerular filtration rate (GFR) groups (≥60 ml/min, 30-60 ml/min, and <30 ml/min)
O
Outcome
All-cause mortality at a median follow-up of 811 dayshard clinical

Patients with baseline renal insufficiency undergoing TAVR have higher rates of peri-procedural stroke and a trend toward higher long-term mortality despite procedural optimization with a minimal contrast approach.

Cite This Study

Rzucidlo et al. (2020) studied this question.

synapsesocial.com/papers/6a719723f44fa9f079df5c70https://doi.org/10.1002/ccd.29378
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Contrast Frugal Approach to Transcatheter Aortic Valve Replacement in Chronic Kidney Disease: A Pilot Study2022 · 1 citations
  2. 2Impact of Pre-existing Kidney Dysfunction on Outcomes Following Transcatheter Aortic Valve Replacement2017 · 12 citations
  3. 3Long‐Term Outcomes of Transcatheter Aortic Valve Replacement in Patients With End‐Stage Renal Disease2021 · 29 citations
  4. 4Prognostic value of renal function in patients with aortic stenosis treated with transcatheter aortic valve replacement2016 · 15 citations
  5. 5In-hospital outcomes of transcatheter aortic valve replacement in patients with chronic and end-stage renal disease: a nationwide database study2024 · 11 citations