Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 3, 2024BMC Cardiovascular DisordersOpen Access

In-hospital outcomes of transcatheter aortic valve replacement in patients with chronic and end-stage renal disease: a nationwide database study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

With TAVR indications expanding, the current impact of CKD and ESRD on post-TAVR in-hospital outcomes needed to be determined.

Does chronic kidney disease or end-stage renal disease increase in-hospital mortality and complications in patients undergoing transcatheter aortic valve replacement compared to normal renal function?

Population

279,195 patients undergoing TAVR in the National Inpatient Sample

Comparison

CKD vs ESRD vs normal renal function

Design

Nationwide retrospective database study

Authors

MLMarta Lorente‐RosSDSubrat DasAMAaqib H. Malik

Discussion

Loading...

Member takes

Overview

CKD/ESRD patients warrant heightened periprocedural vigilance during TAVR; observational data leaves open whether renal optimization reduces complications.

Structured PICO

Does chronic kidney disease or end-stage renal disease increase in-hospital mortality and complications in patients undergoing transcatheter aortic valve replacement compared to normal renal function?

P
Population
279,195 adults (aged ≥ 18 years) undergoing transcatheter aortic valve replacement (TAVR) in the United States between 2016 and 2020, mean age 78.9 years, 44.4% female. 67.1% had normal renal function, 29.2% had chronic kidney disease (CKD), and 3.7% had end-stage renal disease (ESRD).
I
Intervention
Transcatheter aortic valve replacement (TAVR) in patients with chronic kidney disease (CKD) or end-stage renal disease (ESRD)
C
Comparator
Transcatheter aortic valve replacement (TAVR) in patients with normal renal function
O
Outcome
In-hospital all-cause mortalityhard clinical

In a contemporary nationwide cohort, pre-existing CKD and ESRD were associated with a stepwise increase in in-hospital mortality and periprocedural complications following TAVR.

Limitations

  • Retrospective observational nature limits conclusions to in-hospital outcomes
  • Administrative claims-based database lacks clinical outcomes like post-procedural embolic stroke and permanent pacemaker implantation
  • Lacks procedural data such as TAVR access site or whether vascular access complications were related to access site or MCS
  • Absence of laboratory values limits accuracy of AKI definition and CKD staging
  • Lacks information on specific TAVR indication, device type, and surgical risk stratification

Cite This Study

Lorente‐Ros et al. (2024) studied this question.

synapsesocial.com/papers/6a7614a78802f13c0e613be7https://doi.org/10.1186/s12872-023-03684-z
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic kidney disease is not associated with a higher risk for mortality or acute kidney injury in transcatheter aortic valve implantation2012 · 48 citations
  2. 2Comparative Outcomes of Patients With Advanced Renal Dysfunction Undergoing Transcatheter Aortic Valve Replacement in the United States From 2011 to 20142017 · 33 citations
  3. 3Transcatheter Aortic Valve Replacement in Patients With End-Stage Renal Disease2019 · 97 citations
  4. 4Long‐Term Outcomes of Transcatheter Aortic Valve Replacement in Patients With End‐Stage Renal Disease2021 · 31 citations
  5. 5Acute kidney injury post–transcatheter aortic valve replacement2017 · 66 citations