Key result
0.5% levo-bupivacaine provided a significantly faster onset of motor blockade (15.66 vs 19.63 minutes) and longer duration of motor block compared to 0.5% ropivacaine.
Why the study?
Does 0.5% ropivacaine compared to 0.5% levo-bupivacaine improve onset time, duration and quality of analgesia in patients receiving USG guided brachial plexus block?
RCT (n=70)
Triple-blind
Random number table
No
Does 0.5% ropivacaine compared to 0.5% levo-bupivacaine improve onset time, duration and quality of analgesia in patients receiving USG guided brachial plexus block?
Absolute Event Rate: 15.66% vs 19.63%
p-value: p=0.001
0.5% ropivacaine and 0.5% levo-bupivacaine provide comparable duration of postoperative analgesia when used for USG guided supraclavicular brachial plexus block.
Supports interchangeable use of either agent for supraclavicular block; confirms comparable analgesia duration in this RCT.
The study was conducted to compare the onset time, duration and quality of analgesia between 0.5% levo-bupivacaine and 0.5% ropivacaine given in brachial plexus. This prospective, triple blind randomized controlled trial was conducted between January 2020 to December 2021. Seventy patients were randomly allocated into two groups of 35 patients each to receive USG guided brachial plexus block with 30 ml of 0.5% levo-bupivacaine or 30 ml of 0.5%ropivacaine. Blinded observer recorded the onset time and duration of brachial plexus block. Patient characteristics regarding age, weight, and surgical time were comparable in the two groups. The mean onset time of sensory blockade with 0.5% ropivacaine and 0.5%levo-bupivacaine was clinically comparable in our present study. The mean duration of sensory block with 0.5% ropivacaine and 0.5% levo-bupivacaine was also comparable in study. The mean onset time for motor block with 0.5%levo-bupivacaine was lesser than 0.5% ropivacaine. The mean duration of motor block observed in present study with 0.5% ropivacaine was lesser than 0.5% levo-bupivacaine. Mean duration of post operative analgesia of 485.0 ± 76.90 mins (8.08 hrs) was noted with 0.5%ropivacaine and 491.91 ± 92.99 mins (8.2 hrs) with 0.5%levo-bupivacaine which was clinically comparable and the difference was statistically insignificant.
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Kyizom et al. (2022) conducted an RCT in Upper limb orthopaedic surgeries (n=70). 0.5% levo-bupivacaine vs. 30 ml of 0.5% ropivacaine was evaluated on Onset time of motor block (minutes) (p=0.001). 0.5% levo-bupivacaine provided a significantly faster onset of motor blockade (15.66 vs 19.63 minutes) and longer duration of motor block compared to 0.5% ropivacaine.
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