Key result
Pre-angioplasty urokinase widens lumens and enables uneventful stenting in symptomatic carotid stenosis.
Why the study?
Endovascular treatment of cervical carotid artery bifurcation atherosclerosis has been delayed due to concerns about embolic events when crossing diseased arteries with angioplasty catheters.
Does intraarterial thrombolysis with urokinase before angioplasty improve angiographic appearance and procedural safety in patients with symptomatic internal carotid artery stenosis?
Comparison
Intraarterial urokinase thrombolysis before angioplasty and stent placement vs no thrombolysis
Design
Case report
Authors
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May support urokinase pretreatment before carotid angioplasty; leaves open safety and efficacy in prospective trials.
Case Report (n=2)
Does intraarterial thrombolysis with urokinase before angioplasty improve angiographic appearance and procedural safety in patients with symptomatic internal carotid artery stenosis?
Intraarterial thrombolysis with urokinase prior to carotid angioplasty and stenting may digest intralesional thrombus, potentially decreasing the risk of embolic events during the procedure.
Guterman et al. (1996) conducted a case report in Symptomatic internal carotid artery stenosis (n=2). Thrombolysis with urokinase before balloon angioplasty and stent placement was evaluated on Angiographic appearance and procedural success. Thrombolysis with 100,000 to 200,000 units of urokinase before angioplasty in two patients with symptomatic carotid stenosis resulted in widened arterial lumens and uneventful stent placement.
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