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October 20, 2021Frontiers in NeurologyOpen Access

Animal studies suggest that Vitamin D supplementation may reduce the risk of developing multiple sclerosis and could serve as a potential adjunctive therapy, though high doses may cause hypercalcemia.

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Population

Animal models of multiple sclerosis

Design

Review

Key result

Animal studies suggest that Vitamin D supplementation may reduce the risk of developing multiple sclerosis and could serve as a potential adjunctive therapy, though high doses may cause hypercalcemia.

Authors

MHMichaela Tanja HaindlSHSonja Hochmeister

Discussion

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Overview

Vitamin D in MS remains unproven clinically; animal findings leave open the need for human RCTs to confirm benefit and safety.

Structured PICO

P
Population
Animal models of multiple sclerosis
I
Intervention
Vitamin D

This mini-review summarizes recent findings from animal models regarding the effects and mechanisms of vitamin D in multiple sclerosis.

Limitations

  • Translation of data from preclinical models to humans must be used with caution
  • Clinical trials with patients have revealed mixed data
  • High doses of Vitamin D can cause hypercalcemia

Cite This Study

Haindl et al. (2021) conducted a review in Multiple Sclerosis. Vitamin D was evaluated. Animal studies suggest that Vitamin D supplementation may reduce the risk of developing multiple sclerosis and could serve as a potential adjunctive therapy, though high doses may cause hypercalcemia.

synapsesocial.com/papers/6ab8833a3acf4f08a76fa69ahttps://doi.org/10.3389/fneur.2021.757795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of vitamin D in multiple sclerosis and its mechanisms of action2024
  2. 2VITAMIN D3 IN THE PATHOGENESIS AND CLINICAL COURSE OF MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW OF CURRENT EVIDENCE (2015–2026)2026
  3. 3Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis2020 · 27 citations
  4. 4Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trials2025
  5. 5Observation of vitamin D levels in newly diagnosed multiple sclerosis patients: A case series2024