Key result
Factor V Leiden and MTHFR mutations show no association with premature mortality.
Why the study?
Factor V Leiden and the C677T MTHFR gene mutation are associated with premature vascular disease but have high allele frequencies in European populations, raising questions about their impact on premature death.
Are factor V Leiden and thermolabile MTHFR mutations associated with premature death?
Population
87 UK residents over the age of ninety
Comparison
Allele frequencies compared to general UK population
Design
Cross-sectional genetic prevalence study
Authors
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Similar prevalence in nonagenarians suggests limited effect on longevity; leaves open any contribution to vascular disease.
Cross-Sectional (n=87)
Are factor V Leiden and thermolabile MTHFR mutations associated with premature death?
Absolute Event Rate: 2.9% vs 2.7%
The prevalence of factor V Leiden and thermolabile MTHFR mutations in nonagenarians is similar to the general population, suggesting they are not strong risk factors for premature death.
Rees et al. (1997) conducted a cross-sectional in Premature death (n=87). Factor V Leiden and C677T MTHFR gene mutations vs. General UK population was evaluated on Allele frequency of factor V Leiden. Factor V Leiden and thermolabile MTHFR mutations had allele frequencies of 2.9% and 36% in individuals over 90, similar to the general population, suggesting they do not cause premature death.
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