Key result
Common variations in genes associated with cardiovascular risk, including Factor V Leiden, Prothrombin 20210 G-A, and MTHFR 677 C-T, do not contribute significantly to longevity.
Why the study?
Do common genetic polymorphisms associated with cardiovascular risk (Factor V 1691 G-A, Prothrombin 20210 G-A, MTHFR 677 C-T) affect longevity?
Population
1,169 Turkish individuals, comprising 571 patients with a diagnosis of thrombosis and 598 healthy controls.
Comparison
Evaluation of selected genetic polymorphisms vs Healthy controls of the same age groups
Design
Case-control
Authors
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No basis for testing these variants to predict longevity; leaves open contributions from rarer variants or gene-environment interactions.
Case-Control (n=1,169)
Do common genetic polymorphisms associated with cardiovascular risk (Factor V 1691 G-A, Prothrombin 20210 G-A, MTHFR 677 C-T) affect longevity?
Common genetic variations associated with cardiovascular risk, such as Factor V Leiden and Prothrombin mutations, do not appear to significantly influence human longevity.
Akın et al. (2014) conducted a case-control in Thrombosis (n=1,169). Genetic polymorphisms (Factor V 1691 G-A, Prothrombin 20210 G-A, MTHFR 677 C-T) vs. Healthy controls was evaluated on Longevity (genotype frequencies in old vs young groups). Common variations in genes associated with cardiovascular risk, including Factor V Leiden, Prothrombin 20210 G-A, and MTHFR 677 C-T, do not contribute significantly to longevity.
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