Key result
This review highlights the extraordinary diversity of voltage-gated sodium channels and their broad repertoire of functions in electrical signaling and a huge range of pathologies.
This review highlights the historical discovery and molecular genetic characterization of the voltage-gated sodium channel family and their diverse roles in health and disease.
Alerts clinicians to NaV channel diversity in arrhythmias; leaves open targeted therapies pending prospective validation.
In 2000, with the completion of the human genome project, nine related channels were found to comprise the complete voltage-gated sodium gene family and they were renamed Na V 1.1–Na V 1.9. This millennial event reflected the extraordinary impact of molecular genetics on our understanding of electrical signalling in the nervous system. In this review, studies of animal electricity from the time of Galvani to the present day are described. The seminal experiments and models of Hodgkin and Huxley coupled with the discovery of the structure of DNA, the genetic code and the application of molecular genetics have resulted in an appreciation of the extraordinary diversity of sodium channels and their surprisingly broad repertoire of functions. In the present era, unsuspected roles for sodium channels in a huge range of pathologies have become apparent.
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Wood et al. (2018) conducted a review in Pathologies related to sodium channels. Voltage-gated sodium channels was evaluated. This review highlights the extraordinary diversity of voltage-gated sodium channels and their broad repertoire of functions in electrical signaling and a huge range of pathologies.
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