What question did this study set out to answer?

To review the evolutionary divergence, biophysical specializations, and tissue distribution of voltage-gated sodium channel isoforms, as well as the inherited disorders caused by mutations in their encoding genes.

January 1, 2006Annals of Medicine

Voltage‐gated sodium channels: Action players with many faces

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To review the evolutionary divergence, biophysical specializations, and tissue distribution of voltage-gated sodium channel isoforms, as well as the inherited disorders caused by mutations in their encoding genes.
Literature review summarizing the evolutionary gene duplication events that established the voltage-gated sodium channel gene family.
Evaluation of isoform-specific biophysical properties and tissue-specific expression patterns across cardiac, neuronal, and muscular systems.
Voltage-gated sodium channels mediate the rapid inward current responsible for the action potential upstroke, driving electrical impulse propagation across excitable tissues.
Evolutionary duplication produced distinct channel isoforms exhibiting diverse biophysical kinetics and tissue distributions, whose genetic disruptions cause specific inherited channelopathies.

Design

Review

Implication

Highlights inherited sodium channel disorders for arrhythmia differentials; leaves open prospective validation of variant-specific therapies.

Abstract

Voltage-gated sodium channels are responsible for the upstroke of the action potential and thereby play an important role in propagation of the electrical impulse in excitable tissues like muscle, nerve and the heart. Duplication of the sodium channels encoding genes during evolution generated the sodium channel gene family with the different isoforms differing in biophysical properties and tissue distribution. In this review article, mutations in these genes leading to various inherited disorders are discussed.

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Cite This Study

Koopmann et al. (2006) studied this question.

synapsesocial.com/papers/6a707f4e3ce530166bc2d890 https://doi.org/10.1080/07853890600969072

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Implication

Highlights inherited sodium channel disorders for arrhythmia differentials; leaves open prospective validation of variant-specific therapies.

Voltage‐gated sodium channels: Action players with many faces

Key Points

Implication

Abstract

Discussion

Cite This Study

Voltage‐gated sodium channels: Action players with many faces

Key Points

Implication

Abstract

Discussion

Cite This Study

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