Key result
18F-FDG uptake was significantly higher in head and neck paragangliomas with SDHx mutations versus sporadic tumors (P = 0.002), yielding an 80.0% accuracy for predicting germline mutations.
Why the study?
Does 18F-FDG PET/CT uptake predict SDHx mutation status in patients with head and neck paragangliomas?
Population
60 patients with head and neck paragangliomas (HNPGLs) (total 106 HNPGLs), 53.3% with SDHx mutations.
Comparison
18F-FDG PET/CT imaging vs Sporadic HNPGLs (without SDHx mutations)
Design
Cohort
Authors
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18F-FDG PET/CT uptake is significantly higher in SDHx-mutated head and neck paragangliomas, providing a useful clinical tool to identify patients who should be suspected of having germline mutations.
Observational (n=60)
Does 18F-FDG PET/CT uptake predict SDHx mutation status in patients with head and neck paragangliomas?
p-value: p=0.002
18F-FDG PET/CT uptake is significantly higher in SDHx-mutated head and neck paragangliomas, providing a useful clinical tool to identify patients who should be suspected of having germline mutations.
Blanchet et al. (2014) conducted an observational in Hereditary head and neck paragangliomas (n=60). SDHx mutations vs. Sporadic tumors was evaluated on 18F-FDG uptake (p=0.002). 18F-FDG uptake was significantly higher in head and neck paragangliomas with SDHx mutations versus sporadic tumors (P = 0.002), yielding an 80.0% accuracy for predicting germline mutations.
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