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July 1, 2003Epidemiology

Bias due to Secondary Transmission in Estimation of Attributable Risk From Intervention Trials

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Key result

A mathematical model of infectious diarrheal disease demonstrated that bias in attributable risk estimates from intervention trials is a function of person-to-person transmission.

Population

Mathematical model of community- and household-level disease transmission (infectious diarrheal disease)

Design

Other

Authors

JEJoseph N. S. EisenbergUniversity of MichiganBLBryan LewisBiocomTPTravis C. PorcoUniversidade Federal do Rio de Janeiro

Discussion

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Implication

Transmission dynamics may bias attributable risk estimates in diarrheal intervention trials; leaves open whether transmission-adjusted methods improve validity.

Structured PICO

P
Population
Mathematical model of community- and household-level disease transmission (infectious diarrheal disease)
O
Outcome
Bias in attributable risk estimates

Incorporating dependencies among individuals in a transmission model can quantify and adjust for bias in attributable risk estimates from intervention trials of infectious diseases.

Cite This Study

Eisenberg et al. (2003) studied Infectious diarrheal disease. Mathematical model of disease transmission was evaluated on Bias in attributable risk estimates. A mathematical model of infectious diarrheal disease demonstrated that bias in attributable risk estimates from intervention trials is a function of person-to-person transmission.

synapsesocial.com/papers/6ab89192bc62f0dd5ba6d898https://doi.org/10.1097/01.ede.0000071411.19255.4c
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