Key result
Nucleotide supplementation in FMD vaccinated growing pigs linearly increased gain:feed ratio and nutrient digestibility, and decreased cortisol and epinephrine concentrations (P < 0.05).
Why the study?
Does nucleotide supplementation improve growth performance and reduce vaccine stress in FMD-vaccinated growing pigs?
RCT (n=120)
Allocated based on body weight and sex
Does nucleotide supplementation improve growth performance and reduce vaccine stress in FMD-vaccinated growing pigs?
p-value: p=< 0.05
Nucleotide supplementation in FMD-vaccinated growing pigs improves growth performance, nutrient digestibility, and reduces physiological markers of vaccine stress.
Nucleotide supplementation may benefit FMD-vaccinated pigs; leaves open translation to other species or production settings.
A 6 wk trial was conducted to evaluate the effects of nucleotide supplementation in improving performance, nutrient digestibility, and immune blood profiles so as to reduce foot-and-mouth disease (FMD) vaccine stress in growing pigs. A total of 120 growing pigs [(Yorkshire × Landrace) × Duroc] with an average body weight (BW) of 25.76 ± 1.83 kg were used. Pigs were allocated to one of three treatments (eight pens per treatment; three barrows and two gilts per pen) based on BW and sex. Pigs were injected with FMD vaccine at 84 d of age (2 wk after experiment started). Dietary treatments consisted of (1) CON: corn–soybean-meal-based diet, (2) NUC1: CON + 0.5% nucleotide, and (3) NUC2: CON + 1.0% nucleotide. In the current study, the growth performance of gain:feed ratio (G:F), the apparent total tract digestibility of dry matter and nitrogen was linearly (P < 0.05) increased with the increasing level of nucleotide. After injection, the concentration of cortisol and epinephrine was decreased (P < 0.05) linearly in nucleotide treatments. In conclusion, nucleotide supplementation to FMD vaccinated pigs showed positive effects on improving performance, immune system health, and reducing vaccine stress in growing pigs.
No takes yet. Share an insight, caveat, or question.
Jiao et al. (2018) conducted an RCT in Foot-and-mouth disease (FMD) vaccine stress (n=120). Nucleotide supplementation vs. Corn-soybean-meal-based diet was evaluated on Growth performance (gain:feed ratio), apparent total tract digestibility of dry matter and nitrogen, and concentration of cortisol and epinephrine (p=< 0.05). Nucleotide supplementation in FMD vaccinated growing pigs linearly increased gain:feed ratio and nutrient digestibility, and decreased cortisol and epinephrine concentrations (P < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: