Key result
Fluoxetine and imipramine were both significantly more effective than placebo for treating atypical depression over 10 weeks, with fluoxetine being better tolerated than imipramine.
Why the study?
Does fluoxetine improve symptoms in subjects with DSM-IV major depression with atypical features compared to imipramine or placebo?
Population
154 subjects with DSM-IV major depression who met the Columbia criteria for atypical depression
Comparison
Fluoxetine vs Imipramine or placebo
Design
RCT, randomly assigned, placebo-controlled
Follow-up
10 weeks
Authors
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May favor fluoxetine over imipramine for atypical depression due to tolerability; leaves comparative long-term data open.
RCT (n=154)
randomly assigned
Does fluoxetine improve symptoms in subjects with DSM-IV major depression with atypical features compared to imipramine or placebo?
Fluoxetine is as effective as imipramine for atypical depression but is better tolerated, making it a viable treatment option.
McGrath et al. (2000) conducted an RCT in Major depression with atypical features (n=154). Fluoxetine vs. Imipramine or placebo was evaluated on Effectiveness. Fluoxetine and imipramine were both significantly more effective than placebo for treating atypical depression over 10 weeks, with fluoxetine being better tolerated than imipramine.
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