Extrahepatic Manifestations of Hepatitis C Virus Infection

Letters15 August 1996Extrahepatic Manifestations of Hepatitis C Virus InfectionC. Ferri, MD, L. La Civita, MD, and A.L. Zignego, MDC. Ferri, MDUniversity of Pisa, Pisa, ItalyUniversity of Florence, Florence, ItalySearch for more papers by this author, L. La Civita, MDUniversity of Pisa, Pisa, ItalyUniversity of Florence, Florence, ItalySearch for more papers by this author, and A.L. Zignego, MDUniversity of Pisa, Pisa, ItalyUniversity of Florence, Florence, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-4-199608150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Gumber and Chopra [1] recently reviewed the extrahepatic manifestations of chronic hepatitis C virus (HCV) infection. They focused on the striking association between HCV and mixed cryoglobulinemia. This immune-complex-mediated systemic vasculitis is secondary to “benign” B-lymphocyte expansion.The HCV infection of lymphocytes [2] represents the remote event that triggers chronic B-cell proliferation. The immune system alteration may promote various disorders (mixed cryoglobulinemia, autoimmune hepatitis, porphyria cutanea tarda, membranoproliferative glomerulonephritis, and lung fibrosis. These manifestations could be the result of a variable combination of genetic and environmental factors, HCV mutants [3], and other infectious agents.Here, we point ...References1. Gumber SC, Chopra S. Hepatitis C: a multifaceted disease. Review of extrahepatic manifestations. Ann Intern Med. 1995; 123:615-20. Google Scholar2. Ferri C, Monti M, La Civita L, Longombardo G, Greco F, Pasero G, et al. Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood. 1993; 82:3701-4. Google Scholar3. Zignego AL, Ferri C, Giannini C, Monti M, La Civita L, Careccia G, et al. Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia. Ann Intern Med. 1996; 124:31-4. Google Scholar4. Ferri C, La Civita L, Monti M, Longombardo G, Greco F, Pascro G, et al. Can hepatitis C be complicated by malignant lymphoma? Lancet. 1995; 346:1226-7. Google Scholar5. Ferri C, Caracciolo F, Zignego AL, La Civita L, Monti M, Longombardo G, et al. Hepatitis C virus infection in patients with non-Hodgkin's lymphoma. Br J Haematol. 1994; 88:392-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Pisa, Pisa, ItalyUniversity of Florence, Florence, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChronic hepatitis C genotype 4 infection and interstitial pulmonary fibrosisPotential of carbohydrate-binding agents as therapeutics against enveloped virusesRheumatological Manifestations of Gastrointestinal DiseaseCarbohydrate Binding Agents: Potential Therapeutics with Multiple Inhibitory Actions against Enveloped VirusesManagement of hepatitis C virus in patients with porphyria cutanea tardaAnti-HCV and HCV-RNA prevalence and clinical correlations in cases with non-Hodgkin's lymphomaPrevalence of hepatitis C virus infection in porphyria cutanea tarda: systematic review and meta-analysisV H 1-69 gene is preferentially used by hepatitis C virus–associated B cell lymphomas and by normal B cells responding to the E2 viral antigenDetection of Hepatitis C Virus RNA Sequences in B-Cell Non-Hodgkin LymphomaVasculitides secondary to systemic diseasesInterferon  and Ribavirin Combination Therapy in Patients With Chronic Hepatitis C and Mixed CryoglobulinemiaMixed cryoglobulinaemia: a cross-road between autoimmune and lymphoproliferative disordersHepatitis-C virus infection and cabcer 15 August 1996Volume 125, Issue 4Page: 344KeywordsB cellsChronic hepatitis CHepatitis C virusInfectious hepatitisLymphocytesLymphomaPorphyriaPulmonary fibrosisRNAVasculitis Issue Published: 15 August 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...