Key result
Losartan reduces glioma tumor volume by up to ~65% in preclinical rat models.
Why the study?
The role of AT1 receptor blockage on growth factor synthesis and apoptosis in malignant gliomas was investigated to understand its effects on tumor growth.
Does losartan reduce tumoral growth and growth factor synthesis in C6 glioma models?
Population
Cultured C6 glioma cells and rats with C6 glioma
Comparison
Losartan at doses of 40 or 80 mg/kg vs untreated control
Design
Preclinical experimental study
Authors
Loading...
AT1 blockade inhibits rat glioma growth; hypothesis-generating for human translation and requires clinical trials.
Does losartan reduce tumoral growth and growth factor synthesis in C6 glioma models?
Absolute Event Rate: 19% vs 55%
p-value: p=<0.01
Selective blockage of the AT1 receptor with losartan diminishes tumoral growth in C6 rat glioma models through inhibition of growth factors and promotion of apoptosis.
Arrieta et al. (2005) studied C6 rat glioma (n=120). Losartan vs. Control was evaluated on Tumour volume (p=<0.01). Losartan administration at 40 or 80 mg/kg/day significantly decreased tumoral volume in rats with C6 glioma compared to controls (30 and 19 cm3 vs 55 cm3, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: