Key result
Highest urinary adiponectin tertile linked to ~5.6-fold higher odds of microalbuminuria.
Why the study?
The relationship between urinary adiponectin concentration and vascular complications was unclear and needed assessment.
Is urinary adiponectin concentration associated with microalbuminuria and increased pulse wave velocity in subjects at risk for diabetes?
Cross-Sectional (n=708)
Yes
Is urinary adiponectin concentration associated with microalbuminuria and increased pulse wave velocity in subjects at risk for diabetes?
Odds Ratio: 5.607 (95% CI 3.562–8.828)
p-value: p=<0.001
Increased urinary adiponectin concentration is significantly associated with microalbuminuria and increased arterial stiffness, suggesting its potential as a biomarker for vascular dysfunction.
Urinary adiponectin may signal early vascular risk in at-risk subjects; leaves open its added value beyond albuminuria for risk stratification.
BACKGROUND: A relationship between plasma adiponectin level and a number of metabolic conditions, including insulin resistance, obesity, and type 2 diabetes, has been reported. This study aimed to assess whether urinary adiponectin concentration is correlated with vascular complications. METHODS: The study comprised 708 subjects who enrolled in the Seoul Metro City Diabetes Prevention Program and were carefully monitored from September 2008 to December 2008. Levels of urinary adiponectin were measured using an enzyme linked immunosorbent assay (ELISA) kit (AdipoGen, Korea). Urinary albumin excretion was assessed by the ratio of urinary albumin to creatinine (A/C ratio). Participants were divided into three groups based on tertiles of urinary adiponectin concentration, and we investigated whether urinary adiponectin levels are associated with microalbuminuria and pulse wave velocity. RESULTS: Urinary adiponectin concentrations were significantly higher in subjects with microalbuminuria than subjects with normoalbuminuria (P < 0.001). Urinary adiponectin concentration was positively correlated with age, fasting plasma glucose level, HbA1C level, triglyceride level, HOMA-IR, systolic/diastolic blood pressure, and urinary A/C ratio (all P < 0.05). Subjects in the highest tertile of urinary adiponectin concentration had an increased likelihood of microalbuminuria than those in the lowest tertile (Odds ratio (OR), 6.437; 95% confidence interval (CI), 4.202 to 9.862; P < 0.001). After adjusting for age, sex, and estimated creatinine clearance rate (eCcr), the OR remained significant (OR, 5.607; 95% CI, 3.562 to 8.828; P < 0.001). Backward multiple linear regression analysis revealed urinary adiponectin concentration to be a significant determinant of mean brachial-ankle pulse wave velocity (baPWV). CONCLUSIONS: An increased urinary adiponectin concentration is significantly associated with microalbuminuria and increased mean baPWV. These results suggest that urinary adiponectin may play an important role as a biomarker for vascular dysfunction.
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Jeon et al. (2013) conducted a cross-sectional in Microalbuminuria and arterial stiffness (n=708). High urinary adiponectin concentration vs. Low urinary adiponectin concentration was evaluated on Presence of microalbuminuria (OR 5.607, 95% CI 3.562-8.828, p=<0.001). Subjects in the highest tertile of urinary adiponectin concentration had a significantly increased likelihood of microalbuminuria compared to those in the lowest tertile (OR 5.607).
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