What is the clinical evidence from this study?

Study design: Cohort. Population: Isolated coronary artery bypass grafting (CABG) (n=13488). Intervention: Older age (>75 years) vs. Younger age (<65 years and 65-75 years). Primary outcome: 30-day operative mortality rate (p=<0.0001).

What does this research mean for the field?

Older age (>75 years) is associated with a significantly higher 30-day operative mortality rate after isolated CABG compared to younger patients, with elderly mortality driven by diverse systemic and non-cardiac risk factors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 12, 2011Interactive Cardiovascular and Thoracic SurgeryOpen Access

Age-specific risk stratification in 13488 isolated coronary artery bypass grafting procedures

Q: What are the key findings of this study?

Older age (>75 years) was associated with a significantly higher 30-day operative mortality rate after isolated CABG compared to younger patients (4.3% vs 1.7% in <65 years, P<0.0001).

Q: What does this research mean for the field?

Older age (>75 years) is associated with a significantly higher 30-day operative mortality rate after isolated CABG compared to younger patients, with elderly mortality driven by diverse systemic and non-cardiac risk factors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Age over 75 linked to ~2.5-fold higher 30-day mortality after isolated CABG.

P<0.0001
n=13,488

Why the study?

The precise age-specific risks affecting short-term outcomes after isolated coronary artery bypass grafting have not been fully analyzed.

How does age affect the 30-day operative mortality and risk predictors in patients undergoing isolated CABG?

Population

13,488 patients undergoing isolated CABG from the Japan Adult Cardiovascular Surgery Database

Comparison

Age groups: under 65 vs 65-75 vs over 75 years

Design

Cohort study

Follow-up

30-day

Authors

ASAkihito SaitoThe University of Tokyo NMNoboru MotomuraCross-Cutting Cardiology HMH. MiyataKanazawa Medical University

Discussion

Member takes

Implication

Older age is associated with significantly higher 30-day mortality after isolated CABG, with distinct risk factor profiles across age groups necessitating tailored preoperative evaluation.

Study Design

Type

Cohort (n=13,488)

Multicenter

Yes

Structured PICO

How does age affect the 30-day operative mortality and risk predictors in patients undergoing isolated CABG?

Population

13,488 patients undergoing isolated coronary artery bypass grafting from a Japanese national database, stratified into three age groups to assess 30-day operative mortality.

Exposure

Isolated coronary artery bypass grafting (CABG)

Comparator

Age groups compared against each other (under 65 vs 65-75 vs over 75 years)

Outcome

30-day operative mortality ratehard clinical

Main Result

Absolute Event Rate: 4.3% vs 1.7%

p-value: p=<0.0001

Older age is associated with significantly higher 30-day mortality after isolated CABG, with distinct risk factor profiles across age groups necessitating tailored preoperative evaluation.

Cite This Study

Saito et al. (2011) conducted a cohort in Isolated coronary artery bypass grafting (CABG) (n=13,488). Older age (>75 years) vs. Younger age (<65 years and 65-75 years) was evaluated on 30-day operative mortality rate (p=<0.0001). Older age (>75 years) was associated with a significantly higher 30-day operative mortality rate after isolated CABG compared to younger patients (4.3% vs 1.7% in <65 years, P<0.0001).

synapsesocial.com/papers/6ab8a2f55c2a3f8855075842 https://doi.org/10.1510/icvts.2010.254813

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January 12, 2011Interactive Cardiovascular and Thoracic SurgeryOpen Access

Age-specific risk stratification in 13488 isolated coronary artery bypass grafting procedures

View Full Paper

Ask AI

Bookmark

Key result

Age over 75 linked to ~2.5-fold higher 30-day mortality after isolated CABG.

P<0.0001
n=13,488

Why the study?

The precise age-specific risks affecting short-term outcomes after isolated coronary artery bypass grafting have not been fully analyzed.

How does age affect the 30-day operative mortality and risk predictors in patients undergoing isolated CABG?

Population

13,488 patients undergoing isolated CABG from the Japan Adult Cardiovascular Surgery Database

Comparison

Age groups: under 65 vs 65-75 vs over 75 years

Design

Cohort study

Follow-up

30-day

Authors

ASAkihito SaitoThe University of Tokyo NMNoboru MotomuraCross-Cutting Cardiology HMH. MiyataKanazawa Medical University

Discussion

Member takes

Implication

Older age is associated with significantly higher 30-day mortality after isolated CABG, with distinct risk factor profiles across age groups necessitating tailored preoperative evaluation.

Study Design

Type

Cohort (n=13,488)

Multicenter

Yes

Structured PICO

How does age affect the 30-day operative mortality and risk predictors in patients undergoing isolated CABG?

Population

13,488 patients undergoing isolated coronary artery bypass grafting from a Japanese national database, stratified into three age groups to assess 30-day operative mortality.

Exposure

Isolated coronary artery bypass grafting (CABG)

Comparator

Age groups compared against each other (under 65 vs 65-75 vs over 75 years)

Outcome

30-day operative mortality ratehard clinical

Main Result

Absolute Event Rate: 4.3% vs 1.7%

p-value: p=<0.0001

Older age is associated with significantly higher 30-day mortality after isolated CABG, with distinct risk factor profiles across age groups necessitating tailored preoperative evaluation.

Cite This Study

synapsesocial.com/papers/6ab8a2f55c2a3f8855075842 https://doi.org/10.1510/icvts.2010.254813

Also Consider

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