Key result
Intracoronary viral delivery with nitroglycerine infusion enhances myocardial gene expression post-infarction in swine.
Why the study?
Well-established preclinical evaluations are necessary to determine the efficacy and safety of gene therapy using viral vectors for treating cardiac diseases.
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This protocol standardizes preclinical HF gene therapy testing in animals; leaves open clinical translation pending safety and efficacy trials.
Ishikawa et al. (2011) studied Ischemic Heart Failure. Gene transfer via intracoronary injection of virus with simultaneous nitroglycerine infusion was evaluated. An intracoronary injection of virus with simultaneous nitroglycerine infusion in a swine model of myocardial infarction provides simple and efficient gene transfer with enhanced gene expression.
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