Key result
Moxonidine matches clonidine for blood pressure reduction in CKD with better tolerability.
Why the study?
The comparative effects of clonidine and moxonidine as add-on therapy in patients with chronic kidney disease and hypertension were not well established.
Does moxonidine compared to clonidine improve blood pressure and renal parameters as add-on therapy in patients with chronic kidney disease and hypertension?
RCT (n=181)
Open-label
Randomly divided
No
Does moxonidine compared to clonidine improve blood pressure and renal parameters as add-on therapy in patients with chronic kidney disease and hypertension?
Moxonidine and clonidine demonstrate comparable efficacy in reducing blood pressure and renal parameters when used as add-on therapy in patients with chronic kidney disease and hypertension.
Answers are grounded in this paper and cite their sources.
Comparable efficacy with better tolerability for moxonidine versus clonidine in CKD hypertension; hypothesis-generating and requires randomized confirmation before practice change.
Objectives: To compare the effects of clonidine and moxonidine as add on therapy in patients of chronickidney disease with hypertension.Method: It is an observational study of duration of one year. Patient who fall under the diagnostic criteria ofchronic kidney disease with hypertension were selected randomly from those attending the routine medicineoutpatient department and medicine wardat S.N. Medical College and associated hospital.Result and Conclusion: Study shows a slightly greater reduction in various parameters of chronic kidneydisease like systolic BP, diastolic BP, pulse rate, blood urea, and serum creatinine with moxonidine groupthan clonidine group. But statistically there was no significant difference was found in both groups.
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Chandresh Gupta (2020) conducted an RCT in Chronic kidney disease with hypertension (n=181). Moxonidine vs. Clonidine 0.1mg BD was evaluated on Systolic blood pressure at 12 weeks (p=>0.05). Moxonidine and clonidine produced comparable reductions in blood pressure and renal parameters in patients with chronic kidney disease and hypertension, with no significant difference between the groups, though moxonidine was better tolerated.
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