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January 1, 1992Acta Radiologica

Phlebography as the Gold Standard in Thromboprophylactic Studies?

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Key result

Phlebography shows only moderate-to-substantial inter-observer agreement for diagnosing postoperative thrombosis.

  • kappa 0.60 to 0.83
  • n=241

Why the study?

The uncertainty in the evaluation of phlebography as a diagnostic tool for thrombosis after total hip arthroplasty may affect thromboprophylaxis studies.

What is the inter-observer agreement for phlebography in diagnosing thrombosis after total hip arthroplasty?

Population

241 patients with total hip arthroplasty

Comparison

Phlebography evaluations by 4 independent observers vs final consensus

Design

Observational study with independent blinded evaluations

Follow-up

7 to 11 days after surgery

Authors

LBLars C. BorrisAarhus University HospitalLJLars Nannestad JørgensenUniversity of CopenhagenOHOle HauchServier (France)

Discussion

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Overview

Requires caution in phlebography-based thrombosis diagnosis after hip arthroplasty; leaves open its reliability for thromboprophylaxis trials.

Study Design

Type

Observational (n=241)

Structured PICO

What is the inter-observer agreement for phlebography in diagnosing thrombosis after total hip arthroplasty?

P
Population
241 patients with total hip arthroplasty who had phlebography performed in 451 legs 7 to 11 days after surgery.
E
Exposure
Phlebography performed 7 to 11 days after surgery, evaluated by 4 independent observers
O
Outcome
Inter-observer agreement on the diagnosis of thrombosissurrogate

Main Result

Effect estimate: kappa 0.60 to 0.83

There is a notable factor of uncertainty in the evaluation of phlebography for thrombosis, which should be considered when planning postsurgical thromboprophylaxis studies.

Limitations

  • Uncertainty in evaluation of phlebography may have to be considered when studies on postsurgical thromboprophylaxis are planned

Cite This Study

Borris et al. (1992) conducted an observational in Total hip arthroplasty (n=241). Phlebography was evaluated on Inter-observer agreement on diagnosis of thrombosis (kappa 0.60 to 0.83). Phlebography evaluation by independent observers showed variable agreement on thrombosis diagnosis, with inter-observer kappa values ranging from 0.60 to 0.83.

synapsesocial.com/papers/6ab8a97d03bafb67db137979https://doi.org/10.1177/028418519203300105
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